Programme
Monday March 31st, 2008
| 14:00 – 18:00 | Registration (Rootes Social Building) |
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| 14:15 – 19:00 | BSDB Committee Meeting (SS0.21) |
BSCB Committee Meeting (S003) |
| 17:30 – 19:30 | Dinner (Rootes Restaurant) |
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| 19:30 – 20:30 | BSCB Borden Plenary Lecture - Sirtuins, Aging and Disease (Main Theatre) Lenny Guarente (MIT, USA) Sponsored by Garland Science  |
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| 20:30 – 21:30 | BSDB Plenary Lecture - Endless Flies Most Beautiful : The role of cis-Regulatory Sequences in the Evolution of Novelty and Diversity (Main Theatre) Sean Carroll (University of Wisconsin, USA) Sponsored by Mechanisms of Development  |
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| 21.30 | Student Social Evening (Chancellors Suite) |
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Tuesday April 1st, 2008
| 07.30 – 09.30 | Breakfast (residential delegates only) - Rootes Restaurant | |
| 08.00 – 19.00 | Registration (Rootes Social Building) | |
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SESSION 1: BSDB: Quantitative Analysis and Interpretation of Development Signals Session Chair: Alfonso Martinez Arias (Main Theatre) |
SESSION 1: BSCB: Modulation of Genetic Traits Session Chair: Lenny Guarente (Cinema) |
| 09:00 – 09:30 | S1 - Towards a Statistical Mechanics of Cell Fate Assignations Alfonso Martinez-Arias (University of Cambridge, UK) |
S5 - Energy Metabolism, not Oxidative Stress, Determines Mitochondrial and Systemic Aging Siegfried Hekimi (McGill University, Canada) |
| 09:30 – 09:45 | A1 - Gas1 modifies the Hedgehog the morphogenic gradient David Martinelli (Johns Hopkins University, Baltimore, USA) |
A3 - New Chaperone Complexes for Protein Folding in the Endoplasmic Reticulum of Male Germ Cells Adam Benham (University of Durham, Durham, UK) |
| 09:45 – 10:15 | S2 - Coordinating Lineage Choices in Pluripotent Stem Cells Sally Lowell (University of Edinburgh, UK) |
S6 - Prion-Mediated Epigenetic Regulation in Yeast Mick Tuite (University of Kent, UK) |
| 10:15 – 10:45 | Refreshment Break (Mead Gallery) |
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| 10:45 – 11:15 | S3 - Robustness and Scaling in Embryonic Development Naama Barkai (Weizmann Institute of Science, Israel) |
S7 –Chromatin and Stem Cells Amanda Fisher (Imperial College, London) |
| 11:15 – 11:30 | A2 - Engineering drug-dependent protein alleles: timing of GSK-3b activity during craniofacial development Karen Liu (King's College London, UK) |
A4 - Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung’s disease in Bardet-Biedl syndrome Jonathan Tobin (UCL, London, UK) |
| 11:30 – 12:00 | S4 - Forming and Interpreting Morphogen Gradients Jim Smith, (Wellcome Trust/Cancer Research UK Gurdon Institute, UK) |
S8 - Filaggrin - From Cytoskeleton to Common Skin Disease W.H. Irwin McLean (Dundee, UK) |
| 12:00 – 14:00 | Lunch & Poster Session (Mead Gallery and Art Centre Studio) Workshop - ‘How to get your paper published’ (SS0.21) |
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SESSION 2: BSDB: Gene Networks & The Control of Gene Expression Session Chair: Eileen Furlong (Cinema) |
SESSION 2: BSCB: Biogenesis and Specialization of the Cytoskeleton Session Chair: Pierre Coulombe (Main Theatre) |
| 14:00 – 14:30 | S9 - Gene Regulatory Networks During Development: Dissecting the Logic Eileen Furlong (European Molecular Biology Laboratory, Germany) |
S13 - Building the Centriole, Basal Body and Flagellum – Insights from Trypanosomes to Man Keith Gull (Sir William Dunn School of Pathology, UK) |
| 14:30 – 14:45 | A5 - Identification of Hox-Controlled Regulatory Networks in Drosophila: Making a Haltere Instead of a Wing Anastasios Pavlopoulos (University of Cambridge, UK) |
A7 - The extracellular domain of Smoothened is required for ciliary localisation and maximal Hedgehog pathway activation Pia Aanstad (University of California, USA) |
| 14:45 – 15:15 | S10 - Making and Shaping the Foregut Susan Mango (University of Utah, USA) |
S14 - Spatio-Temporal Regulation of Microtubule Organisation Takashi Toda (Cancer Research UK, UK) |
| 15:15 – 15:45 | Refreshment Break (Mead Gallery) |
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| 15:45 – 16:15 | S11 - How do highly conserved non-coding elements (CNEs) encoded in vertebrate genomic DNA influence the expression of developmental regulators? Greg Elgar (University of London, UK) |
S15 - Making Sense of Cilia: Emerging Ciliopathies Phil Beales (UCL Institute of Child Health, UK) |
| 16:15 – 16:30 | A6 - Transcriptionally Profiling Graded Sonic Hedgehog Identifies a Major Role for Foxj1 in the Specification of the Floor Plate Catarina Cruz (MRC National Institute for Medical Research, London, UK) |
A8 - Nlp Promotes Interphase Microtubule Anchoring through Gamma-Tubulin Recruitment and is Coordinately Regulated by the Centrosomal Kinases Nek2 and Plk1 Guojie Mao (University of Leicester, UK) |
| 16:30 – 17:00 | S12 - Transcriptional Regulation of Complex Genetic Loci During Vertebrate Development Peter Rigby (Institute of Cancer Research, UK) |
S16 - Cell Force and Form: Mechanosensing by Protein Unfolding Michael P. Sheetz (Department of Biological Sciences, Columbia University, New York, USA) |
| 17:00 – 18:00 | BSCB: Hooke Medal Diverse Endocytic Pathways in Mammalian Cells Ben Nichols (MRC-LMB, Cambridge, UK) |
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| 18:00 – 19:00 | BSDB AGM (Main Theatre) |
BSCB AGM (SSO.21) |
| 19:00 – 20:30 | Dinner (Rootes Restaurant) |
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| 20:30 – 21:30 | Poster Session & Trade Exhibition Odd number posters 20:30-21:30 Even number posters 21:30-22:30 (Mead Gallery and Arts Centre Studio) |
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Wednesday April 2nd, 2008
| 07.30 – 09.30 | Breakfast (residential delegates only) - Rootes Restaurant | |
08.00 – 19.30 |
Registration (Rootes Social Building) |
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| SESSION 3: BSDB: Regeneration and Repair Session Chair: Margaret Buckingham (Main Theatre) |
SESSION 3: BSCB: Signalling, the Cytoskeleton and Mechanotransduction Session Chair: Keith Gull (Cinema) |
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09:00 - 09:30 |
S17 - The Role of Pax Genes in Determining the Myogenic Fate and Survival of Skeletal Muscle Stem Cells Margaret Buckingham (Pasteur Institute, France) |
S21 - Mechanobiology and Developmental Control Donald Ingber (Harvard Medical School, USA) |
| 09:30 – 09:45 | A9 - Epithelial progenitor cells in lung development and repair Emma Rawlins (Duke University Medical Centre, USA) |
A11 - Drosophila Dystrophin and Dystroglycan act in a polarity pathway that functions under conditions of energetic stress Robert P. Ray (University of Sussex, UK) |
| 09:45 – 10:15 | S18 - Understanding and Reconstructing the Enteric Nervous System Vassilis Pachnis (MRC National Institute for Medical Research, UK) |
S22 - Regulation of the Actin Cytoskeleton by GTPases and WASP-Family Proteins Laura Machesky (CRUK Beatson Institute for Cancer Research, UK) Sponsored by the Association for International Cancer Research  |
| 10:15 – 10:45 | Refreshment Break (Mead Gallery) |
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| 10:45 – 11:15 | S19 - Hormone Gradients and Transcriptional Readouts in Plant (re)generation Ben Scheres (Utrecht University, Netherlands) |
S23 - Regulation of a Transcriptional Coactivator through Actin Treadmilling Richard Treisman (Cancer Research UK, UK) |
| 11:15 – 11:30 | A10 - Characterization of Scarless Wound Healing in the Axolotl Mathieu Lévesque (Université de Montréal, Canada) |
A12 - Mechanical properties of actomyosin cables during cell intercalation Rodrigo Fernandez-Gonzalez (Sloan-Kettering Institute for Cancer Research, USA) |
| 11:30 – 12:00 | S20 - Regeneration, stem cells and the planarian Schmidtea mediterranea Alejandro Sanchez Alvarado (University of Utah School of Medicine, USA) Sponsored by Cell Press  |
S24 - The Keratin Cytoskeleton: Tinkering with Translation Pierre Coulombe (Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA) |
| 12:00 – 14:00 | Lunch (Mead Gallery and Arts Centre Studio) |
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| Student Workshop - Your chance to ask the panel about careers in science (SSO.21) |
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| SESSION 4: BSDB: Cell Fusion in Development Session Chair: Benjamin Podbilewicz (Cinema) |
SESSION 4: BSCB: Cellular Responses to Protein Misfolding Session Chair: David Ron (Main Theatre) |
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| 14:00 - 14:30 | S25 - First Family of Cell-Cell Fusion Proteins Benjamin Podbilewicz (Technion-Israel Institute of Technology, Israel) |
S29 - Life on the Edge: The Origins and Proliferation of Protein Misfolding Chris Dobson (University of Cambridge, UK) |
| 14:30 – 15:00 | S26 - Myoblast Fusion in Drosophila: Role of FuRMASs and F-actin Branching Renate Renkawitz-Pohl (Philipps-Universitaet Marburg, Germany) |
S30 - The Stress of Protein Misfolding in Neurodegenerative Disease and Aging Rick Morimoto (Northwestern, USA) Sponsored by Cancer Research UK  |
| 15:00 – 15:30 | Refreshment Break (Mead Gallery) |
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| 15:30 – 16:00 | S27 - Studies on Fertilization Using Gene Manipulated Animals and Requirement of Izumo in Sperm-Egg Fusion Masaru Okabe (Osaka University, Japan) |
15:30-15:45 A13 - The Neuron-Specific Chaperone Hsj1 Reduces P-Tau Accumulation and Aggregation Sergey Novoselov (UCL Institute of Ophthalmology, UK) 15:45-16:00 A14 - The ataxia protein sacsin contains molecular chaperone domains and interacts with the proteasome Paul Chapple (Queen Mary University of London, UK) |
| 16:00 – 16:30 | S28 - Fusion and Egg Activation at Fertilization Karl Swann (Cardiff University, UK) |
S31 - Chaperone-Mediated Autophagy: A Selective Mechanism for Lysosomal Degradation Ana Maria Cuervo (Albert Einstein College of Medicine, USA ) |
| 16:30 – 17:00 | BSDB Beddington Medal Talk - The developmental identity of mouse and human embryonic stem cells Paul Tesar (National Institute of Health, USA) |
S32 - Autophagic clearance of Aggregate-Prone Proteins: Therapeutic Implications David Rubinsztein (University of Cambridge UK) |
| 17:15 – 18:15 | BSDB Waddington Medal (Main Theatre) |
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| 18:15 – 19:30 | Poster Session (Mead Gallery and Art Centre Studio) |
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| 20:00 – 01.00 | Conference Dinner (Panorama Suite) |
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Thursday April 3rd, 2008
| 07.30 – 09.30 | Breakfast (residential delegates only) - Rootes Restaurant | |
| 08.00 – 12.00 | Registration (Rootes Social Building) | |
| SESSION 5: BSDB: From Neuronal Identity to Circuit Formation Session Chair: Martyn Goulding (Main Theatre) Session sponsored by Neural Development  |
SESSION 5: BSCB: Control and Regulation of Intracellular Traffic Session Chair: Rick Morimoto (Cinema) |
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| 09:00 – 09:30 | S34 - Genetic approaches for unraveling the neural networks that control locomotion Martyn Goulding (The Salk Institute, La Jolla, USA) |
S38 - Hsp70: J-proteins: Versatile Molecular Chaperone Machines Elizabeth Craig (University of Wisconsin, USA) |
| 09:30 – 09:45 | A15 - Modelling Kallmann Syndrome in the Zebrafish Steven Cadman (King's College London, UK) |
A17 - Altered Lysosomal Calcium Signalling Disrupts Endocytosis, Autophagy and Membrane Traffic Emyr Lloyd-Evans (University of Oxford, UK) |
| 09:45 – 10:15 | S35 - Seeing Retinal Ganglion Cells Beginning to Differentiate Bill Harris (Cambridge University, UK) |
S39 - Rab GTPases, Membrane Traffic and Disease Miguel Seabra (Imperial College, UK ) |
| 10:15 – 10:45 | Refreshment Break (Mead Gallery) |
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| 10:45 – 11:15 | S36 - From Stem Cell to Unique Neuron: Specification of Neuronal Sub-Types by the Sequential Integration of Global, Temporal and Local Cues Stefan Thor (Linköping University, Sweden) |
S40 - Function and Dysfunction of Huntingtin in the Control of Intracellular Dynamics Sandrine Humbert (Institut Curie, France) |
| 11:15 – 11:30 | A16 - TGF-beta signals regulate axon growth in the absence of Smads Julian Ng (King's College London, UK) |
A18 - Identification of Mc2r Receptor Accessory Protein Domains Required for Interaction with Mc2r and Formation of a Functional Acth Responsive Receptor Tom Webb (Queen Mary University London, UK) |
| 11:30 – 12:00 | S37 - Transcriptional Control of Midbrain Dopaminergic Neuron Development Siew-Lan Ang (MRC National Institute for Medical Research, UK) |
S41 - Compartment-Specific Unfolded Protein Responses David Ron (New York University School of Medicine, USA) |
| 12:00 – 14:00 | Lunch (Mead Gallery and Art Centre Studio) CLOSE |
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